Endocrine Abstracts

Background: MEN1 is an autosomal dominant inherited syndrome. Primary hyperparathyroidism, tumors of the endocrine pancreas, and of the pituitary, are the characteristic features of the syndrome.Objective: To present a case of MEN1 in a patient with extreme obesity, causing serious difficulties in diagnostic procedures leading to localization of pancreatic tumors.Case presentation: 22-year-old male with extreme obesity (BMI 59), hy...

Introduction: Isolated corticotropic insufficiency of hypophysis with consecutive secondary adrenal insufficiency is a very rare disease. Literature notes difficulties in proper recognition and necessity of differential diagnosis, including among others chronic fatigue syndrome. In recent years, in Poland we observe more and more frequently setting this diagnosis – only on the basis of low ACTH an cortisol concentrations, despite of proper stimulation with 250 μg<sup...

Background: Obesity poses a considerable threat to health, increasing the likelihood of accompanying conditions such as type 2 diabetes, hypertension, dyslipidemia, and cancer. Ageing results in the accumulation of damaging factors leading to the development of chronic diseases. Inflammation levels, telomere length, level of neurocognitive function, metabolic age serve as acknowledged indicators of biological aging. The prevalence of premature ageing in obesity has been eviden...

Introduction: Pheochromocytomas are rarely diagnosed in pregnancy. The consequences of pheochromocytoma during pregnancy can be devastating for both mother and fetus. Effective treatment requires an accurate and early diagnosis, but sometimes the tumor is diagnosed relatively late, so it is absolutely necessary to respond quickly and effectively.Purpose: The aim of our study is to describe a patient with a history of medullary thyroid cancer who underwen...

Polycyclic aromatic hydrocarbons (PAHs) are common environmental pollutants derived from the incomplete combustion of organic materials. In urban and industrial areas, level of pollution with these compounds is high, which leads to numerous negative health effects. Some literature data indicate the involvement of PAHs in the development of obesity, however, there is no data showing the distribution patterns of PAHs in human adipose tissue (AT) and their impact on the process o...

Introduction: Pheochromocytoma is a rare, usually benign tumor composed of neuroendocrine (chromaffin) cells of the adrenal medulla. It is the cause of secondary arterial hypertension. The biochemical diagnosis of a pheochromocytoma is based on the determination of concentration/excretion of catecholamine metabolites in blood or urine. The most sensitive biomarkers in the biochemical diagnosis of pheochromocytoma are plasma free methanephrines (metanephrine, normetanephrine an...

Introduction: 24-hydroxylase, encoded by a CYP24A1 gene, is a crucial enzyme entailed in catabolism of vitamin D. Loss-of-function mutations of CYP24A1 result in hypercalcemia, not adequately concomitant high levels of 1,25(OH)2D and low PTH levels. The variety of clinical manifestations depends on age – mutations can lead to fatal infantile hypercalcemia among neonates (typically precipitated by supplementation of vitamin D), whereas adults’ symptoms are usually mil...

Background: Vitamin D is a dietary micronutrient responsible for calcium and phosphorus metabolism and multiple extraskeletal actions. The assessment of vitamin D status is commonly based on measurement of 25(OH)D total concentration in serum. However, the usage of LC-MS/MS analytical technique allows to reliably assess a panel of vitamin D metabolites in serum or plasma, which may help to investigate the metabolic paths of vitamin D, especially in populations at risk of defic...

Objective: Withdrawal of the medications prior to screening for primary aldosteronism is problematic, sometimes impossible and probably not necessary as the routine practice. The aim of this study was to evaluate diagnostic accuracy of aldosterone-to-renin ratio in hypertensive patients undergoing laboratory screening for primary aldosteronism without obligatory drug modifications.Methods: Plasma aldosterone and direct renin concentrations from 20 patien...

Irisin is a recently reported, widely discussed new adipo-myokin secreted mainly by muscle tissue. It is a cleaved and secreted part of fibronectin type III domain containing 5, encoded by the FNDC5 gene. Some of the previously published studies claim that alterations of irisin levels in patients affected by thyroid diseases may be connected mainly with accompanying myopathy. However, to date it has not been evaluated, whether the changes in expression of FNDC5</e...